Central Nervous System (CNS) Delivery of Glucocorticoids Is Fine-Tuned by Saturable Transporters at the Blood-CNS Barriers and Nonbarrier Regions

Proper functioning of the hypothalamic-pituitary-adrenal axis depends on the ability of glucocorticoids (GCs), mainly cortisol in humans and corticosterone in rodents, to access brain targets and regulate their own secretion. Being highly lipophilic, GCs have been assumed to passively diffuse throug...

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Main Authors: Mason, Brittany L., Pariante, Carmine M., Jamel, Sara, Thomas, Sarah A.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2010
Teme:
Glucocorticoids-CRH-ACTH-Adrenal
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058749/
https://ncbi.nlm.nih.gov/pubmed/20881247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0554
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