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Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart
AIMS: Anthracyclines such as daunorubicin (DNR) and doxorubicin are effective cancer chemotherapeutic agents, but can induce cardiotoxicity. GATA4 has been shown to serve as a survival factor of cardiac muscle cells, and anthracyclines promote apoptosis in part by down-regulating GATA4. The present...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058732/ https://ncbi.nlm.nih.gov/pubmed/21084315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq361 |
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