LACK OF PROTEIN-TYROSINE SULFATION DISRUPTS PHOTORECEPTOR OUTER SEGMENT MORPHOGENESIS, RETINAL FUNCTION AND RETINAL ANATOMY

To investigate the role(s) of protein-tyrosine sulfation in the retina, we examined retinal function and structure in mice lacking tyrosylprotein sulfotransferases (TPST) 1 and 2. Tpst double knockout (DKO; Tpst1(−/−)/Tpst2(−/−)) retinas had drastically reduced electroretinographic responses, althou...

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Detalhes bibliográficos
Main Authors: Sherry, David M., Murray, Anne R., Kanan, Yogita, Arbogast, Kelsey L., Hamilton, Robert A., Fliesler, Steven J., Burns, Marie E., Moore, Kevin L., Al-Ubaidi, Muayyad R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058723/
https://ncbi.nlm.nih.gov/pubmed/21039965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2010.07431.x
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