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Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in non-insulin-dependent Otsuka Long-Evans Tokushima Fatty rats

BACKGROUND: It is well established that the pathogenesis of diabetic nephropathy is associated with abnormalities of renal nitric oxide (NO) generation. Many of the biological actions of NO are mediated by cGMP, which is rapidly degraded by phosphodiesterases. In this study, we evaluated the renopro...

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Detalhes bibliográficos
Main Authors: Kuno, Yoshihiro, Iyoda, Masayuki, Shibata, Takanori, Hirai, Yuki, Akizawa, Tadao
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058170/
https://ncbi.nlm.nih.gov/pubmed/21133896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01149.x
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