Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

A hallmark of human papillomavirus (HPV) associated carcinogenesis is the integration of the viral DNA into the cellular genome, usually accompanied by the loss of expression of the viral E2 gene. E2 binds to and represses the viral promoter directing expression of the E6 and E7 oncogenes. The re-in...

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Bibliografische Detailangaben
Veröffentlicht in:	EMBO J
Hauptverfasser:	Wells, Susanne I., Francis, Delicia A., Karpova, Alla Y., Dowhanick, Jennifer J., Benson, John D., Howley, Peter M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2000
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305788/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11060027/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.21.5762
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Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

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