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ATP Induces Conformational Changes in the Carboxyl-terminal Region of ClC-5
ATP binding enhances the activity of ClC-5, the transporter mutated in Dent disease, a disease affecting the renal proximal tubule. Previously, the ATP binding site was revealed in x-ray crystal structures of the cytoplasmic region of this membrane protein. Disruption of this site by mutagenesis (Y6...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057859/ https://ncbi.nlm.nih.gov/pubmed/21173145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175877 |
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