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New Alkaloid Antibiotics That Target the DNA Topoisomerase I of Streptococcus pneumoniae
Streptococcus pneumoniae has two type II DNA-topoisomerases (DNA-gyrase and DNA topoisomerase IV) and a single type I enzyme (DNA-topoisomerase I, TopA), as demonstrated here. Although fluoroquinolones target type II enzymes, antibiotics efficiently targeting TopA have not yet been reported. Eightee...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057782/ https://ncbi.nlm.nih.gov/pubmed/21169356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.148148 |
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