X-Inactivation Reveals Epigenetic Anomalies in Most hESC but Identifies Sublines That Initiate as Expected

The clinical and research value of human embryonic stem cells (hESC) depends upon maintaining their epigenetically naïve, fully undifferentiated state. Inactivation of one X chromosome in each cell of mammalian female embryos is a paradigm for one of the earliest steps in cell specialization through...

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Main Authors: HALL, LISA L., BYRON, MEG, BUTLER, JOHN, BECKER, KLAUS A., NELSON, ANGEL, AMIT, MICHAL, ITSKOVITZ-ELDOR, JOSEPH, STEIN, JANET, STEIN, GARY, WARE, CAROL, LAWRENCE, JEANNE B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057623/
https://ncbi.nlm.nih.gov/pubmed/18340642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21411
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