Double negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells

A relatively rare aldehyde dehydrogenase 1 (ALDH1) positive “stem cell-like” subpopulation of tumor cells has the unique ability to initiate and perpetuate tumor growth; moreover it is highly resistant to chemotherapy and significantly associated with poor clinical outcomes. The development of more...

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Hauptverfasser: Yang, Xiaojun, Lin, Xiaojuan, Zhong, Xiaomin, Kaur, Sippy, Li, Ning, Liang, Shun, Lassus, Heini, Wang, Liping, Katsaros, Dionyssios, Montone, Kathleen, Zhao, Xia, Zhang, Youcheng, Bützow, Ralf, Coukos, George, Zhang, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057570/
https://ncbi.nlm.nih.gov/pubmed/21045151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2388
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