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MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells
BACKGROUND & AIMS: Lysophosphatidic acid (LPA) is a potent inducer of colon cancer and LPA receptor type 2 (LPA2) is overexpressed in colon tumors. LPA2 interacts with membrane-associated guanylate kinase with inverted orientation-3 (MAGI-3) and the Na+/H+ exchanger regulatory factor 2 (NHERF-2)...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057353/ https://ncbi.nlm.nih.gov/pubmed/21134377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.11.054 |
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