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Why target PIM1 for cancer diagnosis and treatment?

The highly conserved proto-oncogenic protein PIM1 is an unusual serine or threonine kinase, in part because it is constitutively active. Overexpression of PIM1 experimentally leads to tumor formation in mice, while complete knockout of the protein has no observable phenotype. It appears to contribut...

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Bibliografiske detaljer
Main Authors: Magnuson, Nancy S, Wang, Zeping, Ding, Gang, Reeves, Raymond
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057053/
https://ncbi.nlm.nih.gov/pubmed/20919829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.10.106
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