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Why target PIM1 for cancer diagnosis and treatment?
The highly conserved proto-oncogenic protein PIM1 is an unusual serine or threonine kinase, in part because it is constitutively active. Overexpression of PIM1 experimentally leads to tumor formation in mice, while complete knockout of the protein has no observable phenotype. It appears to contribut...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057053/ https://ncbi.nlm.nih.gov/pubmed/20919829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.10.106 |
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