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West Nile virus (WNV) genome RNAs with up to three adjacent mutations that disrupt long distance 5′-3′ cyclization sequence basepairs are viable
Mosquito-borne flavivirus genomes contain conserved 5′ and 3′ cyclization sequences (CYC) that facilitate long distance RNA-RNA interactions. In previous studies, flavivirus replicon RNA replication was completely inhibited by single or multiple mismatching CYC nt substitutions. In the present study...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056923/ https://ncbi.nlm.nih.gov/pubmed/21292293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.01.008 |
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