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Secreted cathepsin L generates endostatin from collagen XVIII

Endostatin, an inhibitor of angiogenesis and tumor growth, was identified originally in conditioned media of murine hemangioendothelioma (EOMA) cells. N–terminal amino acid sequencing demonstrated that it corresponds to a fragment of basement membrane collagen XVIII. Here we report that cathepsin L...

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Detalhes bibliográficos
Main Authors: Felbor, Ute, Dreier, Lars, Bryant, Rebecca A.R., Ploegh, Hidde L., Olsen, Bjorn R., Mothes, Walther
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC305660/
https://ncbi.nlm.nih.gov/pubmed/10716919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.6.1187
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