Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1

Architecturally defective, leaky blood vessels typify pathologic angiogenesis induced by vascular endothelial growth factor-A (VEGF-A). Such neovascular defects aggravate disease pathology and seriously compromise the therapeutic utility of VEGF. Endothelial cell (EC) transduction with active L61Rac...

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Bibliographic Details
Main Authors: Hoang, Mien V., Nagy, Janice A., Senger, Donald R.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056599/
https://ncbi.nlm.nih.gov/pubmed/21030561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-286831
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