Regulation of the oncoprotein KLF8 by a switch between acetylation and sumoylation

KLF8 regulates target genes by recruiting the p300 and PCAF co-activators via glutamines (Q) 118 and 248, the CtBP co-repressor to 86PVDLS90 or SUMO to lysine (K) 67. Here we examined how these interactions coordinate to regulate KLF8 transactivity. Mass spectrometry and immunoprecipitations determi...

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Detalhes bibliográficos
Main Authors: Urvalek, Alison M, Lu, Heng, Wang, Xianhui, Li, Tianshu, Yu, Lin, Zhu, Jinghua, Lin, Qishan, Zhao, Jihe
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056558/
https://ncbi.nlm.nih.gov/pubmed/21416054
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