Induction of CD8(+) T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

PURPOSE: A phase I/II trial was performed to evaluate the safety and immunogenicity of a novel vaccination with α-type 1 polarized dendritic cells (αDC1) loaded with synthetic peptides for glioma-associated antigen (GAA) epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stab...

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Main Authors: Okada, Hideho, Kalinski, Pawel, Ueda, Ryo, Hoji, Aki, Kohanbash, Gary, Donegan, Teresa E., Mintz, Arlan H., Engh, Johnathan A., Bartlett, David L., Brown, Charles K., Zeh, Herbert, Holtzman, Matthew P., Reinhart, Todd A., Whiteside, Theresa L., Butterfield, Lisa H., Hamilton, Ronald L., Potter, Douglas M., Pollack, Ian F., Salazar, Andres M., Lieberman, Frank S.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2011
Teme:
Original Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056467/
https://ncbi.nlm.nih.gov/pubmed/21149657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.30.7744
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