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Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
The transcription factor FKHR is inhibited by phosphorylation in response to insulin and IGF–1 through Akt kinase. Here we show that FKHR phosphorylation in hepatocytes conforms to a hierarchical pattern in which phosphorylation of the Akt site at S(253), in the forkhead DNA binding domain, is a pre...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2000
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305638/ https://ncbi.nlm.nih.gov/pubmed/10698940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.5.989 |
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