A randomised, placebo-controlled trial of dutasteride in spinal and bulbar muscular atrophy

BACKGROUND: Spinal and bulbar muscular atrophy (SBMA) is caused by polyglutamine expansion in the androgen receptor, which results in ligand-dependent toxicity. Animal models have a neuromuscular deficit that is mitigated by androgen-reducing treatment. METHODS: We explored the efficacy and safety o...

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Detalhes bibliográficos
Main Authors: Fernández-Rhodes, Lindsay E, Kokkinis, Angela D, White, Michelle J, Watts, Charlotte A, Auh, Sungyoung, Jeffries, Neal O, Shrader, Joseph A, Lehky, Tanya J, Li, Li, Ryder, Jennifer E, Levy, Ellen W, Solomon, Beth I, Harris-Love, Michael O, La Pean, Alison, Schindler, Alice B, Chen, CheunJu, Di Prospero, Nicholas A, Fischbeck, Kenneth H
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056353/
https://ncbi.nlm.nih.gov/pubmed/21216197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(10)70321-5
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