RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice

OBJECTIVE: To investigate the impact of reduced adipocyte fatty acid-binding protein 4 (FABP4) in control of body weight, glucose and lipid homeostasis in diet-induced obese (DIO) mice. METHODS: We applied RNA interference (RNAi) technology to generate FABP4 germline knockdown mice to investigate th...

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Detalhes bibliográficos
Main Authors: Yang, R, Castriota, G, Chen, Y, Cleary, M A, Ellsworth, K, Shin, M K, Tran, J-Lv, Vogt, T F, Wu, M, Xu, S, Yang, X, Zhang, B B, Berger, J P, Qureshi, S A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056343/
https://ncbi.nlm.nih.gov/pubmed/20603627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2010.128
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