Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation

While islet transplantation is an effective treatment for Type 1 diabetes, primary engraftment failure contributes to suboptimal outcomes. We tested the hypothesis that islet isolation and transplantation activate innate immunity through Toll-like receptors (TLR) expressed on islets. Murine islets c...

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Main Authors: Krüger, Bernd, Yin, Na, Zhang, Nan, Yadav, Anju, Coward, William, Lal, Girdhari, Zang, Weiping, Heeger, Peter, Bromberg, Jonathan S., Murphy, Barbara, Schröppel, Bernd
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056019/
https://ncbi.nlm.nih.gov/pubmed/20809521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040601
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