Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer

BACKGROUND: Inhibitors of the kinase mTOR, such as rapamycin and everolimus, have been used as cancer therapeutics with limited success since some tumours are resistant. Efforts to establish predictive markers to allow selection of patients with tumours likely to respond have centred on determining...

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Detalhes bibliográficos
Main Authors: Satheesha, Sampoorna, Cookson, Victoria J, Coleman, Louise J, Ingram, Nicola, Madhok, Brijesh, Hanby, Andrew M, Suleman, Charlotte AB, Sabine, Vicky S, Macaskill, E Jane, Bartlett, John MS, Dixon, J Michael, McElwaine, Jim N, Hughes, Thomas A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055230/
https://ncbi.nlm.nih.gov/pubmed/21320304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-19
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