Kinetics of isoniazid transfer into cerebrospinal fluid in patients with tuberculous meningitis.

For the pharmacokinetic analysis of isoniazid transfer into CSF, steady-state isoniazid concentrations of plasma and CSF were measured in eleven tuberculous meningitis patients confirmed with findings of CSF and neuroimazing. Peak plasma levels (4.17-21.5 micrograms/mL) were achieved at 0.25 to 3 ho...

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Autori principali: Shin, S. G., Roh, J. K., Lee, N. S., Shin, J. G., Jang, I. J., Park, C. W., Myung, H. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Academy of Medical Sciences 1990
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053720/
https://ncbi.nlm.nih.gov/pubmed/2206465
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