Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate

TEM-72, a class A β-lactamase identified in isolates of Enterobacteriaceae, is a quadruple mutant of TEM-1 (Q39K, M182T, G238S and E240K) and shows extended-spectrum β-lactamase (ESBL) properties arising from the G238S and E240K substitutions. Although many structures of TEM variants have been publi...

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Bibliographic Details
Main Authors: Docquier, Jean-Denis, Benvenuti, Manuela, Calderone, Vito, Rossolini, Gian-Maria, Mangani, Stefano
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2011
Subjects:
Structural Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053151/
https://ncbi.nlm.nih.gov/pubmed/21393831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110054680
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