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The effect of charge-reversal amphiphile spacer composition on DNA and siRNA delivery

A series of charge-reversal amphiphiles with different spacers separating the head group from the hydrophobic chains are described for delivery of DNA and siRNA. Among them, the amphiphiles possessing a glycine spacer (e.g., B-GlyGly) showed effective DNA transfection in CHO and NIH 3T3 cells as wel...

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Detalhes bibliográficos
Main Authors: Zhang, Xiao-Xiang, Prata, Carla A. H., McIntosh, Thomas J., Barthélémy, Philippe, Grinstaff, Mark W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052776/
https://ncbi.nlm.nih.gov/pubmed/20433165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc9005464
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