Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is an aggressive, rapidly progressive malignancy without effective therapy. We evaluate sorafenib efficacy and impact on the cellular pro-survival machinery in vitro, efficacy of sorafenib as monotherapy and in combination with the naturally occurring death recep...

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Autori principali: Katz, Sharyn I., Zhou, Lanlan, Chao, Grace, Smith, Charles D., Ferrara, Thomas, Wang, Wenge, Dicker, David T., El-Deiry, Wafik S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052759/
https://ncbi.nlm.nih.gov/pubmed/20038816
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