Role of Reactive Oxygen Species in Hyper-Adrenergic Hypertension: Biochemical, Physiological, and Pharmacological Evidence from Targeted Ablation of the Chromogranin A (Chga) Gene

BACKGROUND: Oxidative stress, an excessive production of reactive oxygen species (ROS) outstripping antioxidant defense mechanisms, occurs in cardiovascular pathologies including hypertension. Here, we used biochemical, physiological, and pharmacological approaches to explore the role of derangement...

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Main Authors: Gayen, Jiaur R., Zhang, Kuixing, RamachandraRao, Satish P., Mahata, Manjula, Chen, Yuqing, Kim, Hyung-Suk, Naviaux, Robert K., Sharma, Kumar, Mahata, Sushil K., O'Connor, Daniel T.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052689/
https://ncbi.nlm.nih.gov/pubmed/20729505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.109.924050
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