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Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

Mitochondrial complex I dysfunction is regarded as underlying dopamine neuron death in Parkinson’s disease models. However, inactivation of the Ndufs4 gene, which compromises complex I activity, does not affect the survival of dopamine neurons in culture or in the substantia nigra pars compacta of 5...

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Detalhes bibliográficos
Main Authors: Choi, Won-Seok, Palmiter, Richard D., Xia, Zhengui
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051820/
https://ncbi.nlm.nih.gov/pubmed/21383081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201009132
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