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Mitochondrial dysfunction in distal axons contribute to HIV sensory neuropathy

OBJECTIVE: Accumulation of mitochondrial DNA (mtDNA) damage has been associated with aging and abnormal oxidative metabolism. We hypothesized that in human immunodeficiency virus associated sensory neuropathy (HIV-SN), damaged mtDNA accumulates in distal nerve segments and that a spatial pattern of...

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Autori principali: Lehmann, Helmar C., Chen, Weiran, Borzan, Jasenka, Mankowski, Joseph, Höke, Ahmet
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051401/
https://ncbi.nlm.nih.gov/pubmed/21280080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22150
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