NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations

The proinflammatory transcription factor nuclear factor-kappaB (NF-κB) plays a central role in host defence against pneumococcal disease. Both rare mutations and common polymorphisms in the NFKBIA gene encoding the NF-κB inhibitor IκB-α associate with susceptibility to bacterial disease, but the pos...

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Bibliographic Details
Main Authors: Chapman, Stephen J, Khor, Chiea C, Vannberg, Fredrik O, Rautanen, Anna, Segal, Shelley, Moore, Catrin E, Davies, Robert J O, Day, Nicholas P, Peshu, Norbert, Crook, Derrick W, Berkley, James A, Williams, Thomas N, Scott, J Anthony, Hill, Adrian V S
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3051152/
https://ncbi.nlm.nih.gov/pubmed/19798075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2009.76
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