Antibiotic dosing in the 'at risk' critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients

BACKGROUND: Critical illness, mediated by trauma or sepsis, can lead to physiological changes that alter the pharmacokinetics of antibiotics and may result in sub-therapeutic concentrations at the sites of infection. The first aim of this project is to identify the clinical characteristics of critic...

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Autores principales: Roberts, Jason A, Roberts, Michael S, Semark, Andrew, Udy, Andrew A, Kirkpatrick, Carl MJ, Paterson, David L, Roberts, Matthew J, Kruger, Peter, Lipman, Jeffrey
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Study Protocol
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050838/
https://ncbi.nlm.nih.gov/pubmed/21333028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2253-11-3
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