The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein

BACKGROUND: The UL97 protein kinase of human cytomegalovirus phosphorylates the antiviral drug ganciclovir and is the target of maribavir action. A detailed enzyme kinetic analysis of maribavir on the various enzymatic functions of wild type and ganciclovir resistant forms of UL97 is required. METHO...

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Bibliographic Details
Main Authors: Shannon-Lowe, Claire D, Emery, Vincent C
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050433/
https://ncbi.nlm.nih.gov/pubmed/21429239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2042-4280-1-4
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