Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice

The apolipoprotein E4 (APOE4) gene leads to increased brain amyloid beta (Aβ) and poor outcome in adults with traumatic brain injury (TBI); however, its role in childhood TBI is controversial. We hypothesized that the transgenic expression of human APOE4 worsens the outcome after controlled cortical...

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Detalhes bibliográficos
Main Authors: Mannix, Rebekah C, Zhang, Jimmy, Park, Juyeon, Zhang, Xuan, Bilal, Kiran, Walker, Kendall, Tanzi, Rudolph E, Tesco, Giuseppina, Whalen, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049498/
https://ncbi.nlm.nih.gov/pubmed/20588316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.99
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