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Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation

The glutamate–glutamine cycle faces a drain of glutamate by oxidation, which is balanced by the anaplerotic synthesis of glutamate and glutamine in astrocytes. De novo synthesis of glutamate by astrocytes requires an amino group whose origin is unknown. The deficiency in Aralar/AGC1, the main mitoch...

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מידע ביבליוגרפי
Main Authors: Pardo, Beatriz, Rodrigues, Tiago B, Contreras, Laura, Garzón, Miguel, Llorente-Folch, Irene, Kobayashi, Keiko, Saheki, Takeyori, Cerdan, Sebastian, Satrústegui, Jorgina
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049464/
https://ncbi.nlm.nih.gov/pubmed/20736955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.146
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