Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation

The glutamate–glutamine cycle faces a drain of glutamate by oxidation, which is balanced by the anaplerotic synthesis of glutamate and glutamine in astrocytes. De novo synthesis of glutamate by astrocytes requires an amino group whose origin is unknown. The deficiency in Aralar/AGC1, the main mitoch...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pardo, Beatriz, Rodrigues, Tiago B, Contreras, Laura, Garzón, Miguel, Llorente-Folch, Irene, Kobayashi, Keiko, Saheki, Takeyori, Cerdan, Sebastian, Satrústegui, Jorgina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049464/
https://ncbi.nlm.nih.gov/pubmed/20736955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.146
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge