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Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation
The glutamate–glutamine cycle faces a drain of glutamate by oxidation, which is balanced by the anaplerotic synthesis of glutamate and glutamine in astrocytes. De novo synthesis of glutamate by astrocytes requires an amino group whose origin is unknown. The deficiency in Aralar/AGC1, the main mitoch...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049464/ https://ncbi.nlm.nih.gov/pubmed/20736955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.146 |
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