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Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation

An expanded polyglutamine tract (>37 glutamines) in the N-terminal region of huntingtin (htt) causes htt to accumulate in the nucleus, leading to transcriptional dysregulation in Huntington disease (HD). In HD knock-in mice that express full-length mutant htt at the endogenous level, mutant htt p...

詳細記述

保存先:
書誌詳細
主要な著者: Havel, Lauren S., Wang, Chuan-En, Wade, Brandy, Huang, Brenda, Li, Shihua, Li, Xiao-Jiang
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049362/
https://ncbi.nlm.nih.gov/pubmed/21245084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr023
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