Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith–Wiedemann syndrome and Silver–Russell syndrome

Hyper- and hypomethylation at the IGF2-H19 imprinting control region (ICR) result in reciprocal changes in IGF2-H19 expression and the two contrasting growth disorders, Beckwith–Wiedemann syndrome (BWS) and Silver–Russell syndrome (SRS). DNA methylation of the ICR controls the reciprocal imprinting...

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Bibliographic Details
Main Authors: Nativio, Raffaella, Sparago, Angela, Ito, Yoko, Weksberg, Rosanna, Riccio, Andrea, Murrell, Adele
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049359/
https://ncbi.nlm.nih.gov/pubmed/21282187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr018
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