Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.
Extracts from bovine pituitary were found to contain an activity catalyzing the conversion of glutaminyl peptides such as [Gln1]gonadotropin-releasing hormone, [Gln1, Gly4]thyrotropin-releasing hormone (H-Gln-His-Pro-Gly-OH), and H-Gln-Tyr-Ala-OH to the respective pyroglutamyl peptides. The TRH prec...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1987
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304928/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3473473/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.11.3628 |
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