Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.
Three mouse monoclonal antibodies were produced that reacted with the alpha subunit of the human insulin receptor. All three both immunoprecipitated 125I-labeled insulin receptors from IM-9 lymphocytes and competitively inhibited 125I-labeled insulin binding to its receptor. Unlike insulin, the anti...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1987
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304888/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3033648/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.10.3448 |
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