Meta-Analysis confirms CR1, CLU, and PICALM as Alzheimer’s disease risk loci and reveals interactions with APOE genotypes

OBJECTIVES: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer’s disease (AD) and whether risk for AD associated with these genes is influenced by APOE genotypes. DESIGN: Association study of AD and CLU, PICALM, CR1 and APOE genotypes. SETTING: Academic research institu...

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Main Authors: Jun, Gyungah, Naj, Adam C., Beecham, Gary W., Wang, Li-San, Buros, Jacqueline, Gallins, Paul J., Buxbaum, Joseph D., Ertekin-Taner, Nilufer, Fallin, M. Daniele, Friedland, Robert, Inzelberg, Rivka, Kramer, Patricia, Rogaeva, Ekaterina, St George-Hyslop, Peter, Cantwell, Laura B., Dombroski, Beth A., Saykin, Andrew J., Reiman, Eric M., Bennett, David A., Morris, John C., Lunetta, Kathryn L., Martin, Eden R., Montine, Thomas J., Goate, Alison M., Blacker, Deborah, Tsuang, Debby W., Beekly, Duane, Cupples, L. Adrienne, Hakonarson, Hakon, Kukull, Walter, Foroud, Tatiana M., Haines, Jonathan, Mayeux, Richard, Farrer, Lindsay A., Pericak-Vance, Margaret A., Schellenberg, Gerard D.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048805/
https://ncbi.nlm.nih.gov/pubmed/20697030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archneurol.2010.201
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