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Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

Fibrosis is a pathological process characterized by infiltration and proliferation of mesenchymal cells in interstitial space. A substantial portion of these cells is derived from residing non-epithelial and/or epithelial cells that have acquired the ability to migrate and proliferate. The mesenchym...

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Detalhes bibliográficos
Main Authors: Doi, Shigehiro, Zou, Yonglong, Togao, Osamu, Pastor, Johanne V., John, George B., Wang, Lei, Shiizaki, Kazuhiro, Gotschall, Russell, Schiavi, Susan, Yorioka, Noriaki, Takahashi, Masaya, Boothman, David A., Kuro-o, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048747/
https://ncbi.nlm.nih.gov/pubmed/21209102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.174037
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