Premature Ligand-Receptor Interaction during Biosynthesis Limits the Production of Growth Factor Midkine and Its Receptor LDL Receptor-related Protein 1

Protein production within the secretory pathway is accomplished by complex but organized processes. Here, we demonstrate that the growth factor midkine interacts with LDL receptor-related protein 1 (LRP1) at high affinity (K(d) value, 2.7 nm) not only at the cell surface but also within the secretor...

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Main Authors: Sakamoto, Kazuma, Bu, Guojun, Chen, Sen, Takei, Yoshifumi, Hibi, Kenji, Kodera, Yasuhiro, McCormick, Lynn M., Nakao, Akimasa, Noda, Masaharu, Muramatsu, Takashi, Kadomatsu, Kenji
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048725/
https://ncbi.nlm.nih.gov/pubmed/21212259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176479
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