Premature Ligand-Receptor Interaction during Biosynthesis Limits the Production of Growth Factor Midkine and Its Receptor LDL Receptor-related Protein 1

Protein production within the secretory pathway is accomplished by complex but organized processes. Here, we demonstrate that the growth factor midkine interacts with LDL receptor-related protein 1 (LRP1) at high affinity (K(d) value, 2.7 nm) not only at the cell surface but also within the secretor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sakamoto, Kazuma, Bu, Guojun, Chen, Sen, Takei, Yoshifumi, Hibi, Kenji, Kodera, Yasuhiro, McCormick, Lynn M., Nakao, Akimasa, Noda, Masaharu, Muramatsu, Takashi, Kadomatsu, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048725/
https://ncbi.nlm.nih.gov/pubmed/21212259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176479
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados