Creating Directed Double-strand Breaks with the Ref Protein: A NOVEL RecA-DEPENDENT NUCLEASE FROM BACTERIOPHAGE P1

The bacteriophage P1-encoded Ref protein enhances RecA-dependent recombination in vivo by an unknown mechanism. We demonstrate that Ref is a new type of enzyme; that is, a RecA-dependent nuclease. Ref binds to ss- and dsDNA but does not cleave any DNA substrate until RecA protein and ATP are added t...

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Detalhes bibliográficos
Main Authors: Gruenig, Marielle C., Lu, Duo, Won, Sang Joon, Dulberger, Charles L., Manlick, Angela J., Keck, James L., Cox, Michael M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048710/
https://ncbi.nlm.nih.gov/pubmed/21193392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.205088
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