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Lack of cAMP-response Element-binding Protein 1 in the Hypothalamus Causes Obesity
The melanocortin system in the hypothalamus controls food intake and energy expenditure. Its disruption causes severe obesity in mice and humans. cAMP-response element-binding protein 1 (CREB1) has been postulated to play an important role downstream of the melanocortin-4 receptor (MC4R), but this h...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048696/ https://ncbi.nlm.nih.gov/pubmed/21209091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.178186 |
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