The pH-regulated Antigen 1 of Candida albicans Binds the Human Complement Inhibitor C4b-binding Protein and Mediates Fungal Complement Evasion

Candida albicans binds and utilizes human complement inhibitors, such as C4b-binding protein (C4BP), Factor H, and FHL-1 for immune evasion. Here, we identify Candida pH-regulated antigen 1 (Pra1) as the first fungal C4BP-binding protein. Recombinant Pra1 binds C4BP, as shown by ELISA and isothermal...

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Detalhes bibliográficos
Main Authors: Luo, Shanshan, Blom, Anna M., Rupp, Steffen, Hipler, Uta-Christina, Hube, Bernhard, Skerka, Christine, Zipfel, Peter F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048689/
https://ncbi.nlm.nih.gov/pubmed/21212281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.130138
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