Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy

BACKGROUND: Genetic fusion of the major birch pollen allergen (Bet v1) to bacterial surface-(S)-layer proteins resulted in recombinant proteins exhibiting reduced allergenicity as well as immunomodulatory capacity. Thus, S-layer/allergen fusion proteins were considered as suitable carriers for new i...

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Bibliographic Details
Main Authors:	Ilk, Nicola, Schumi, Christian-Thomas, Bohle, Barbara, Egelseer, Eva Maria, Sleytr, Uwe B
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2011
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3048495/ https://ncbi.nlm.nih.gov/pubmed/21310062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-10-6
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Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy

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