Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes

BACKGROUND: Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes...

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Autores principales: Lange, Nancy E, Zhou, Xiaobo, Lasky-Su, Jessica, Himes, Blanca E, Lazarus, Ross, Soto-Quirós, Manuel, Avila, Lydiana, Celedón, Juan C, Hawrylowicz, Catherine M, Raby, Benjamin A, Litonjua, Augusto A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048492/
https://ncbi.nlm.nih.gov/pubmed/21324137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-12-26
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