Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS

Amino acid oxidation is known to affect the structure, activity, and rate of degradation of proteins. Methionine oxidation is one of the several chemical degradation pathways for recombinant antibodies. In this study, we have identified for the first time a solvent accessible tryptophan residue (Trp...

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Detalhes bibliográficos
Principais autores: Hensel, Miriam, Steurer, Rebecca, Fichtl, Juergen, Elger, Carsten, Wedekind, Frank, Petzold, Andreas, Schlothauer, Tilman, Molhoj, Michael, Reusch, Dietmar, Bulau, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048405/
https://ncbi.nlm.nih.gov/pubmed/21390239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017708
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