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A nonsense mutation causes hereditary goitre in the Afrikander cattle and unmasks alternative splicing of thyroglobulin transcripts.

The hereditary goitre of Afrikander cattle is an autosomal recessive disease characterized in homozygotes by the production of abnormal thyroglobulin (Tg) and the coexistence in the thyroid of normal-sized 8.4-kilobase (kb) Tg mRNA with a misspliced 7.3-kb message having lost exon 9. We have cloned...

詳細記述

保存先:
書誌詳細
主要な著者: Ricketts, M H, Simons, M J, Parma, J, Mercken, L, Dong, Q, Vassart, G
フォーマット: Artigo
言語:Inglês
出版事項: 1987
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC304832/
https://ncbi.nlm.nih.gov/pubmed/3472203
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